Pianeta (363) (1893 S)

363 Ellaway.qxd

Background. There are many reasons why people frequently consult their general practitioner (GP). Although loneliness is increasingly recognized as a problem affecting wellbeing for elderly people, it has rarely been addressed as a predictor of frequency of consultation. Aim. To examine whether loneliness is associated with rates of GP consultations (home and surgery visits). Method. Analysis o...

C0sm00879f 363..368

Fabrication of precisely designed active biomaterials is of great interest in many areas of bionanotechnology including regenerative medicine, drug screening, and biosensors. Microand nanometre scale defined patterns have been developed which can control the spacing and density of signaling molecules through top-down microfabrication approaches, such as photolithography, e-beam lithography, and...

Bez nazwy-363

Dev113472 363..374

Epithelial remodelling is an essential mechanism for organogenesis, during which cells change shape and position while maintaining contact with each other. Adherens junctions (AJs) mediate stable intercellular cohesion but must be actively reorganised to allow morphogenesis. Vesicle trafficking and the microtubule (MT) cytoskeleton contribute to regulating AJs but their interrelationship remain...

Op-brai150105 1875..1893

Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of fibroblast growth factor 9 (FGF9), which we demonstrate inhibits myelination and remyelination ...